Ponce de Leon returned to Florida in 1521, planning to establish a colony between the Caloosahatchee River and Charlotte Harbor on the west coast of Florida. He took two ships and 200 colonists. The Calusa Tribe attacked the settlers as soon as they came ashore and a poisoned arrow hit Ponce de Leon in the leg. The colonists returned to Havana in July 1521, where Ponce de Leon died of his wounds.
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